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Salmonellosis, a disease caused by non-typhoidal  Salmonella  strains which can be transmitted from swine to humans, is one of the leading public health problems around the world. Paratyphoid of swine is controlled by vaccinating swine with  Salmonella enterica  serovar Choleraesuis ( S.  Choleraesuis) live vaccine strain C500 in China. Although the vaccine has good prophylactic efficacy, the mechanism of immunogenicity is unclear. Using a C500-derived paratyphoid thermo-stable live vaccine (PTSL vaccine), we demonstrated that the PTSL vaccine induces strong primary and memory immune responses in piglets. Mucosal IgA and IFN-γ + /CD8 +  T cells induced by the PTSL vaccine play key roles in the protection of the host from  Salmonella  infection. Our findings have important implications on the development of new and improved vaccines against salmonellosis and using live-attenuated  Salmonella  as vaccine carriers.

Mucosal IgA and IFN-γ+ CD8 T cell immunity are important in the efficacy of live Salmonella enteria serovar Choleraesuis vaccines