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Dendritic Ca 2+  spike endows cortical pyramidal cell with powerful ability of synaptic integration, which is critical for neuronal computation. Here we propose a two-compartment conductance-based model to investigate how the Ca 2+  activity of apical dendrite participates in the action potential (AP) initiation to affect the firing properties of pyramidal neurons. We have shown that the apical input with sufficient intensity triggers a dendritic Ca 2+  spike, which significantly boosts dendritic inputs as it propagates to soma. Such event instantaneously shifts the limit cycle attractor of the neuron and results in a burst of APs, which makes its firing rate reach a plateau steady-state level. Delivering current to two chambers simultaneously increases the level of neuronal excitability and decreases the threshold of input-output relation. Here the back-propagating APs facilitate the initiation of dendritic Ca 2+  spike and evoke BAC firing. These findings indicate that the proposed model is capable of reproducing  in vitro  experimental observations. By determining spike initiating dynamics, we have provided a fundamental link between dendritic Ca 2+  spike and output APs, which could contribute to mechanically interpreting how dendritic Ca 2+  activity participates in the simple computations of pyramidal neuron.

Action potential initiation in a two-compartment model of pyramidal neuron mediated by dendritic Ca2+ spike