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Ovine footrot is a highly prevalent bacterial disease caused by  Dichelobacter nodosus  and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high  D. nodosus  load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation.  Treponema  (34%),  Mycoplasma  (29%) and  Porphyromonas  (15%) were the most abundant genera associated with high levels of inflammation in footrot. In contrast,  Acinetobacter  (25%),  Corynebacteria  (17%) and  Flavobacterium  (17%) were the most abundant genera associated with high levels of inflammation in healthy feet. This demonstrates for the first time there is a distinct microbial community associated with footrot and high cytokine expression.

A distinct bacterial dysbiosis associated skin inflammation in ovine footrot