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To find the genetic markers related to the antipsychotic-induced weight gain (AIWG), we analyzed associations among candidate gene single-nucleotide polymorphisms (SNPs) and quantitative traits of weight changes and lipid profiles in a Chinese Han population. A total of 339 schizophrenic patients, including 86 first-episode patients (FEPs), meeting the entry criteria were collected. All patients received atypical antipsychotic drug monotherapy and hospitalization and were followed for 12 weeks. Forty-three SNPs in 23 candidate genes were calculated for quantitative genetic association with AIWG, performed by PLINK. The  TOX  gene SNP rs11777927 ( P  = 0.009) and the  ADIPOQ  gene SNP rs182052 ( P  = 0.019) were associated with AIWG (in body mass index, BMI). In addition, the  BDNF  SNP rs6265 ( P  = 0.002),  BDAF  SNP rs11030104 SNP ( P  = 0.001), and  ADIPOQ  SNPs rs822396 ( P  = 0.003) were significantly associated with the change of waist-to-hip ratio (WHR) induced by atypical antipsychotics. These results were still significant after age and gender adjustments. These findings provide preliminary evidence supporting the role of  TOX, ADIPOQ  and  BDNF  in weight and WHR gain induced by atypical antipsychotics.

TOX and ADIPOQ Gene Polymorphisms Are Associated with Antipsychotic-Induced Weight Gain in Han Chinese