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More and more new natural products have been found in  Streptomyces  species, which become the significant resource for antibiotics production. Among them,  Streptomyces lydicus  has been known as its ability of streptolydigin biosynthesis. Herein, we present the genome analysis of  S. lydicus  based on the complete genome sequencing. The circular chromosome of  S. lydicus  103 comprises 8,201,357 base pairs with average GC content 72.22%. With the aid of KEGG analysis, we found that  S. lydicus  103 can transfer propanoate to succinate, glutamine or glutamate to 2-oxoglutarate, CO 2  and L-glutamate to ammonia, which are conducive to the the supply of amino acids.  S. lydicus  103 encodes acyl-CoA thioesterase II that takes part in biosynthesis of unsaturated fatty acids, and harbors the complete biosynthesis pathways of lysine, valine, leucine, phenylalanine, tyrosine and isoleucine. Furthermore, a total of 27 putative gene clusters have been predicted to be involved in secondary metabolism, including biosynthesis of streptolydigin, erythromycin, mannopeptimycin, ectoine and desferrioxamine B. Comparative genome analysis of  S. lydicus  103 will help us deeply understand its metabolic pathways, which is essential for enhancing the antibiotic production through metabolic engineering.

Complete genome sequencing and antibiotics biosynthesis pathways analysis of Streptomyces lydicus 103