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Considering the biological roles of  WNT4  and  WNT5A  involved in adipogenesis, we aimed to investigate whether SNPs in  WNT4  and  WNT5A  contribute to obesity related traits in Han Chinese population. Targeted genomic sequence for  WNT4  and  WNT5A  was determined in 100 Han Chinese subjects and tag SNPs were selected. Both single SNP and SNP × SNP interaction association analyses with body mass index (BMI) were evaluated in the 100 subjects and another independent sample of 1,627 Han Chinese subjects. Meta-analyses were performed and multiple testing corrections were carried out using the Bonferroni method. Consistent with the Genetic Investigation of ANthropometric Traits (GIANT) dataset results, we didn’t detect significant association signals in single SNP association analyses. However, the interaction between rs2072920 and rs11918967, was associated with BMI after multiple testing corrections (combined  P  = 2.20 × 10 −4 ). The signal was also significant in each contributing data set. SNP rs2072920 is located in the 3′-UTR of  WNT4  and SNP rs11918967 is located in the intron of  WNT5A . Functional annotation results revealed that both SNPs might be involved in transcriptional regulation of gene expression. Our results suggest that a combined effect of SNPs via  WNT4 - WNT5A  interaction may affect the variation of BMI in Han Chinese population.

SNP-SNP interactions between WNT4 and WNT5A were associated with obesity related traits in Han Chinese Population