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Gene expression is a noisy process and several mechanisms, bothtranscriptional and posttranscriptional, can stabilize protein levels in cells.Much work has focused on the role of miRNAs, showing in particular thatmiRNA-mediated regulation can buffer expression noise for lowly expressedgenes. Here, using in silico simulations and mathematical modeling, wedemonstrate that miRNAs can exert a much broader influence on protein levels byorchestrating competition-induced crosstalk between mRNAs. Most notably, wefind that miRNA-mediated cross-talk (i) can stabilize protein levels across thefull range of gene expression rates, and (ii) modifies the correlation patternof co-regulated interacting proteins, changing the sign of correlations fromnegative to positive. The latter feature may constitute a potentially robustsignature of the existence of RNA crosstalk induced by endogenous competitionfor miRNAs in standard cellular conditions.

ceRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins