English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Germacrane-type sesquiterpenes, with a flexible 10-membered ring unit as the structural and conformational features, play a central role in the biosynthesis and synthesis of other sesquiterpenes. In this report, two pairs of new sesquiterpene alkaloids, (+)/(−)-phaeocaulin A [(+)- 1 /(−)- 1 ] and B [(+)- 2 /(−)- 2 ], and two pairs of new sesquiterpenes, (+)/(−)-phaeocaulin C [(+)- 3 /(−)- 3 ] and D [(+)- 4 /(−)- 4 ], along with one related known analog ( 5 ), were isolated from the rhizomes of  Curcuma phaeocaulis . The absolute configurations of (+)- 1 /(−)- 1 , (+)- 2 /(−)- 2 , (+)- 3 /(−)- 3  and (+)- 4 /(−)- 4  were unambiguously determined by analysis of single-crystal X-ray diffractions and quantum chemical electronic circular dichroism (ECD) method. It is noteworthy that (+)/(−)-phaeocaulin A [(+)- 1 /(−)- 1 ] and B [(+)- 2 /(−)- 2 ] are two pairs of rare N-containing germacrane-type sesquiterpenes. A possible biogenetic pathway for  1–5  was postulated. All of the isolated compounds were tested for their inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages.

(+)/(−)-Phaeocaulin A-D, four pairs of new enantiomeric germacrane-type sesquiterpenes from Curcuma phaeocaulis as natural nitric oxide inhibitors