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FOSL1  (FOS like antigen 1) is one kind of proto-oncogene, and may play a vital role in carcinogenesis of multiple cancers. However, studies about the relationship between SNPs in  FOSL1  and gastric cancer are still lacking. Thus, we investigated the association of seven SNPs in  FOSL1  with gastric cancer using case-control design in a two-stage strategy (Screening stage: 1,140 gastric cancer cases and 1,547 controls; Replication stage: 1,006 cases and 2,273 controls). We found that rs1892901 was significantly associated with increased risk of gastric cancer in additive model (adjusted OR = 1.25, 95%CI: 1.06–1.47,  P  = 0.008) in first stage. Following replication results revealed that the relationship between rs1892901 and gastric cancer risk was consistent with our primary results.  In silico  analysis showed that rs1892901 might alter multiple regulatory motifs, disturb protein binding, and affect the expression of  FOSL1  and other important gastric cancer-related genes such as  EGR1, CHD, EP300, FOS, JUN  and  FOSL2.  Our findings indicated that functional SNP rs1892901 in  FOSL1  might affect the expression of  FOSL1 , and ultimately increase the risk of gastric cancer. Further functional studies and large-scale population studies are warranted to confirm our findings.

A functional SNP rs1892901 in FOSL1 is associated with gastric cancer in Chinese population