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The mechanisms involved in the chronic hepatitis C progression are incompletely understood. The aim was to analyze the association between  2 ′ 5 ′ oligoadenylate synthetase 1,2 and 3 (OAS1-3 ) and  myxovirus resistance proteins 1 (Mx1 ) polymorphisms and severity of liver disease in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. We performed a cross-sectional study in 219 patients that underwent a liver biopsy. DNA genotyping for  Mx1  (rs469390),  OAS1  (rs2285934),  OAS2  (rs1293762) and  OAS3  (rs2010604) was performed by using GoldenGate assay. The outcome variables ion liver biopsy were: (i) significant fibrosis (F ≥ 2); (ii) moderate activity grade (A ≥ 2). Additive model of inheritance for genetic association test was used. The likelihood of having significant fibrosis (F ≥ 2) was lower in patients carrying  OAS2  rs1293762 A allele [adjusted odds ratio (aOR) = 0.51; p = 0.040]. Besides, the likelihood of having moderate activity grade (A ≥ 2) was higher in patients carrying  Mx1  rs464397 C allele (aOR = 1.63; p = 0.028) and  Mx1  rs469390 G allele (aOR = 1.97; p = 0.005), while it was lower in patients carrying  OAS1  rs2285934 A allele (aOR = 0.64; p = 0.039) and  OAS2  rs1293762 A allele (aOR = 0.41; p = 0.009). In conclusion,  Mx1  and  OAS1-2  polymorphisms were associated with the severity of liver disease in HIV/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis.

Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study