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Ovo , which encodes a transcription factor with Zn-finger domains, is evolutionarily conserved among animals. In  Drosophila , in addition to its zygotic function for egg production, maternal  ovo  activity is required in primordial germ cells (PGCs) for expression of germline genes such as  vasa  and  nanos . In this study, we found that maternal Ovo accumulates in PGC nuclei during embryogenesis. In these cells,  ovo  serves a dual function: activation of genes expressed predominantly in PGCs, and conversely suppression of somatic genes. Reduction of  ovo  activity in PGCs makes them unable to develop normally into germ cells of both sexes. In mice, knockout of the  ovo  ortholog,  Ovol2 , which is expressed in PGCs, decreases the number of PGCs during early embryogenesis. These data strongly suggest that  ovo  acts as part of an evolutionarily conserved mechanism that regulates germline development in animals.

Conserved role of Ovo in germline development in mouse and Drosophila