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Benzothiazole, a microbial secondary metabolite, has been demonstrated to possess fumigant activity against  Sclerotinia sclerotiorum ,  Ditylenchus destructor  and  Bradysia odoriphaga . However, to facilitate the development of novel microbial pesticides, the mode of action of benzothiazole needs to be elucidated. Here, we employed iTRAQ-based quantitative proteomics analysis to investigate the effects of benzothiazole on the proteomic expression of  B. odoriphaga . In response to benzothiazole, 92 of 863 identified proteins in  B. odoriphaga  exhibited altered levels of expression, among which 14 proteins were related to the action mechanism of benzothiazole, 11 proteins were involved in stress responses, and 67 proteins were associated with the adaptation of  B. odoriphaga  to benzothiazole. Further bioinformatics analysis indicated that the reduction in energy metabolism, inhibition of the detoxification process and interference with DNA and RNA synthesis were potentially associated with the mode of action of benzothiazole. The myosin heavy chain, succinyl-CoA synthetase and Ca + -transporting ATPase proteins may be related to the stress response. Increased expression of proteins involved in carbohydrate metabolism, energy production and conversion pathways was responsible for the adaptive response of  B. odoriphaga . The results of this study provide novel insight into the molecular mechanisms of benzothiazole at a large-scale translation level and will facilitate the elucidation of the mechanism of action of benzothiazole.

Proteomic profile of the Bradysia odoriphaga in response to the microbial secondary metabolite benzothiazole