English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Dengue virus (DENV) is a mosquito-transmitted virus imposing a significant burden on human health around the world. Since current control strategies are not sufficient, there is an urgent need to find alternative methods to control DENV transmission. It has been demonstrated that introduction of  Wolbachia pipientis  in  Aedes aegypti  mosquitoes can impede DENV transmission with the mechanism(s) not fully understood. Recently, a number of studies have found the involvement of chromodomain DNA binding helicases in case of Human Immunodeficiency virus (HIV) and Influenza A virus infection. In this study, we have identified three chromodomain helicase DNA binding protein ( CHD ) genes in  Ae. aegypti  and looked at their response in the case of  Wolbachia  and DENV infections. Foremost amongst them we have found that  AeCHD7 / Kismet  is significantly downregulated in the presence of  Wolbachia  infection only in female mosquitoes. Furthermore,  AeCHD7  levels showed significant increase during DENV infection, and  AeCHD7  depletion led to severe reduction in the replication of DENV. Our data have identified  AeCHD7  as a novel  Ae. aegypti  host factor that is important for DENV replication, and  Wolbachia  downregulates it, which may contribute towards the mechanism(s) of limiting DENV replication.

Downregulation of Aedes aegypti chromodomain helicase DNA binding protein 7/Kismet by Wolbachia and its effect on dengue virus replication