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Increased risk of developing metabolic syndrome (MetS) has been associated with the  APOA5 ,  APOC1 ,  BRAP ,  BUD13 ,  CETP ,  LIPA ,  LPL ,  PLCG1 , and  ZPR1  genes. In this replication study, we reassessed whether these genes are associated with MetS and its individual components independently and/or through complex interactions in a Taiwanese population. We also analyzed the interactions between environmental factors and these genes in influencing MetS and its individual components. A total of 3,000 Taiwanese subjects were assessed in this study. Metabolic traits such as waist circumference, triglyceride, high-density lipoprotein (HDL) cholesterol, systolic and diastolic blood pressure, and fasting glucose were measured. Our data showed a nominal association of MetS with the  APOA5  rs662799,  BUD13  rs11216129,  BUD13  rs623908,  CETP  rs820299, and  LIPA  rs1412444 single nucleotide polymorphisms (SNPs). Moreover,  APOA5  rs662799,  BUD13  rs11216129, and  BUD13  rs623908 were significantly associated with high triglyceride, low HDL, triglyceride, and HDL levels. Additionally, we found the interactions of  APOA5  rs662799,  BUD13  rs11216129,  BUD13  rs623908,  CETP  rs820299,  LIPA  rs1412444, alcohol consumption, smoking status, or physical activity on MetS and its individual components. Our study indicates that the  APOA5 ,  BUD13 ,  CETP , and  LIPA  genes may contribute to the risk of MetS independently as well as through gene-gene and gene-environment interactions.

Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population