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The purpose of this study was to investigate the differential expression and functional roles of long non-coding RNAs (lncRNAs) in neuroblastoma tissue. LncRNA microarrays were used to identify differentially expressed lncRNAs between tumor and para-tumor tissues. In total, in tumor tissues, 3,098 and 1,704 lncRNAs were upregulated and downregulated, respectively.  HCN3  and  linc01105  exhibited the higher expression (P < 0.05; P < 0.01, respectively) in neuroblastoma tissue, whereas  MEG3  displayed the lower expression (P < 0.01).  HIF-1α  expression was negatively correlated with cell proliferation in the  linc01105  KD group. In addition,  Noxa  and  Bid  expression was positively correlated with cell apoptosis. Moreover,  linc01105  knockdown promoted cell proliferation, whereas  MEG3  overexpression inhibited proliferation. Finally,  linc01105  knockdown,  MEG3  overexpression and  HCN3  knockdown all increased apoptosis. The correlation coefficients between those three lncRNAs and the International Neuroblastoma Staging System (INSS) stage were −0.48, −0.58 and −0.55, respectively. In conclusion, we have identified lncRNAs that are differentially expressed in neuroblastoma tissues. The lncRNAs  HCN3, linc01105 , and  MEG3  may be important in biological behaviors of neuroblastoma through mechanisms involving p53 pathway members such as  HIF-1α, Noxa , and  Bid . The expressions of  MEG3, HCN3  and  linc01105  are all negatively correlated with the INSS stage.

MEG3, HCN3 and linc01105 influence the proliferation and apoptosis of neuroblastoma cells via the HIF-1α and p53 pathways