English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Electrochemical scaffolds (e-scaffolds) continuously generate low concentrations of H 2 O 2  suitable for damaging wound biofilms without damaging host tissue. Nevertheless, retarded diffusion combined with H 2 O 2  degradation can limit the efficacy of this potentially important clinical tool. H 2 O 2  diffusion into biofilms and bacterial cells can be increased by damaging the biofilm structure or by activating membrane transportation channels by exposure to hyperosmotic agents. We hypothesized that e-scaffolds would be more effective against  Acinetobacter baumannii  and  Staphylococcus aureus  biofilms in the presence of a hyperosmotic agent. E-scaffolds polarized at −600 mV Ag/AgCl  were overlaid onto preformed biofilms in media containing various maltodextrin concentrations. E-scaffold alone decreased  A. baumannii  and  S. aureus  biofilm cell densities by (3.92 ± 0.15) log and (2.31 ± 0.12) log, respectively. Compared to untreated biofilms, the efficacy of the e-scaffold increased to a maximum (8.27 ± 0.05) log reduction in  A. baumannii  and (4.71 ± 0.12) log reduction in  S. aureus  biofilm cell densities upon 10 mM and 30 mM maltodextrin addition, respectively. Overall ~55% decrease in relative biofilm surface coverage was achieved for both species. We conclude that combined treatment with electrochemically generated H 2 O 2  from an e-scaffold and maltodextrin is more effective in decreasing viable biofilm cell density.

Maltodextrin enhances biofilm elimination by electrochemical scaffold