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Viruses are one of the main drivers of the decline of domesticated and wild bees but the mechanisms of antiviral immunity in pollinators are poorly understood. Recent work has suggested that next to the small interfering RNA (siRNA) pathway other immune-related pathways play a role in the defense of the bee hosts against viral infection. In addition, Vago plays a role in the cross-talk between the innate immune pathways in  Culex  mosquito cells. Here we describe the Vago orthologue in bumblebees of  Bombus terrestris , and investigated its role upon the infection of two different bee viruses, the virulent Israeli acute paralysis virus (IAPV) and the avirulent slow bee paralysis virus (SBPV). Our results showed that  Bt Vago was downregulated upon the infection of IAPV that killed all bumblebees, but not with SBPV where the workers survived the virus infection. Thus, for the first time,  Vago/Vago-like  expression appears to be associated with the virulence of virus and may act as a modulator of antiviral immunity.

Differential expression pattern of Vago in bumblebee (Bombus terrestris), induced by virulent and avirulent virus infections