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Candida albicans  is an opportunistic human fungal pathogen. The ability to switch among multiple cellular forms is key to its pathogenesis. The Dbf4-dependent protein kinase gene  CDC7  is conserved due to its role in initiating DNA replication. Because a  C. albicans  Cdc7 ( Cacdc7 ) homozygous null was not viable, we generated a  C. albicans  strain with a deleted  C. albicans CDC7 (CaCDC7 ) allele and an expression-repressible allele. Surprisingly, cells of the strain grew as hyphae under the repressed conditions. The  in vitro  kinase assays confirmed that  Ca Cdc7 (K232) and  Ca Cdc7 (T437) are critical for catalytic and phosphoacceptor of activation activity, respectively.  C. albicans  cells formed hyphae when expressing either the catalytically inactive  Ca Cdc7 (K232R) or the phosphoacceptor-deficient  Ca Cdc7 (T437A). While  Ca Cdc7 interacted with  Ca Dbf4, cells of the strain in which  CaCDC7  was repressed were not rescued by constitutively expressing  C. albicans DBF4  or vice versa. We conclude that  CaDBF4 -dependent  CaCDC7  is an essential gene suppressing the hyphal development.

Candida albicans Dbf4-dependent Cdc7 kinase plays a novel role in the inhibition of hyphal development