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Duplication, lateral gene transfer, domain fusion/fission and  de novo  domain creation play a key role in formation of initial common ancestral protein. Abundant protein diversities are produced by domain rearrangements, including fusions, fissions, duplications, and terminal domain losses. In this report, we explored the origin of the RPW8 domain and examined the domain rearrangements that have driven the evolution of RPW8-encoding genes in land plants. The RPW8 domain first emerged in the early land plant,  Physcomitrella patens , and it likely originated  de novo  from a non-coding sequence or domain divergence after duplication. It was then incorporated into the NBS-LRR protein to create a main sub-class of RPW8-encoding genes, the RPW8-NBS-encoding genes. They evolved by a series of genetic events of domain fissions, fusions, and duplications. Many species-specific duplication events and tandemly duplicated clusters clearly demonstrated that species-specific and tandem duplications played important roles in expansion of RPW8-encoding genes, especially in gymnosperms and species of the Rosaceae. RPW8 domains with greater  Ka / Ks  values than those of the NBS domains indicated that they evolved faster than the NBS domains in RPW8-NBSs.

A unique RPW8-encoding class of genes that originated in early land plants and evolved through domain fission, fusion, and duplication