English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Although CD4 +  T cells are recognized to play an important role in the inflammatory response of nasal polyps (NPs), the biological functions of CD8 +  T cells in polypogenesis remain unclear. In this study, we analyzed cell markers, cytokine expression and transcription factors in IL-21-expressing CD8 +  T cells in polyp tissues of NP patients. The results showed that the majority of IL-21-producing CD8 +  T cells were effector memory cells and they co-expressed IFN-γ. IL-21-expressing CD8 +  T cells in polyp tissues expressed higher CXCR5, PD-1, and ICOS levels than cells in control tissues and showed significantly higher T-bet and Bcl-6 expression levels compared with IL-21 − CD8 +  T cells. Purified polyp CD8 +  T cells promoted IgG production from isolated polyp B cells  in vitro , and recombinant IL-12 modulated the expression of IL-21, IFN-γ and CD40L in purified polyp CD8 +  T cells. Moreover, the percentage of IL-21 + CD8 +  T cells in polyp tissues was positively correlated with endoscopic and CT scan scores in NP patients. These findings indicated that polyp CD8 +  T cells, by co-expressing IL-21 and IFN-γ and other markers, display a Tfh cell functionality, which is associated with the clinical severity of NP patients.

Phenotypic and functional characteristics of IL-21-expressing CD8+ T cells in human nasal polyps