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Zika virus (ZIKV) is causing an explosive outbreak of febrile disease in the Americas. There are no effective antiviral therapies or licensed vaccines for this virus, and mosquito control strategies have not been adequate to contain the virus. A promising candidate for arbovirus control and prevention relies on the introduction of the intracellular bacterium  Wolbachia  into  Aedes aegypti  mosquitoes. This primarily has been proposed as a tool to control dengue virus (DENV) transmission; however, evidence suggests  Wolbachia  infections confer protection for  Ae. aegypti  against other arboviruses. At present, it is unknown whether or not ZIKV can infect, disseminate, and be transmitted by  Wolbachia- infected  Ae. aegypti . Using  Ae. aegypti  infected with the  w Mel strain of  Wolbachia  that are being released in Medellin, Colombia, we report that these mosquitoes have reduced vector competence for ZIKV. These results support the use of  Wolbachia  biocontrol as a multivalent strategy against  Ae. aegypti -transmitted viruses.

The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti