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A lack of relevant disease models for  Campylobacter jejuni  has long been an obstacle to research into this common enteric pathogen. Here we used an infant rabbit to study  C. jejuni  infection, which enables us to define several previously unknown but key features of the organism.  C. jejuni  is capable of systemic invasion in the rabbit, and developed a diarrhea symptom that mimicked that observed in many human campylobacteriosis. The large intestine was the most consistently colonized site and produced intestinal inflammation, where specific cytokines were induced. Genes preferentially expressed during  C. jejuni  infection were screened, and  acs ,  cj1385 ,  cj0259  seem to be responsible for  C. jejuni  invasion. Our results demonstrates that the infant rabbit can be used as an alternative experimental model for the study of diarrheagenic  Campylobacter  species and will be useful in exploring the pathogenesis of other related pathogens.

Insights into Campylobacter jejuni colonization and enteritis using a novel infant rabbit model