English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Recently, a genome-wide analysis identified DNA methylation of the  HIF3A  ( hypoxia-inducible factor 3A ) as strongest correlate of BMI. Here we tested the hypothesis that  HIF3A  mRNA expression and CpG-sites methylation in adipose tissue (AT) and genetic variants in  HIF3A  are related to parameters of AT distribution and function. In paired samples of subcutaneous AT (SAT) and visceral AT (VAT) from 603 individuals, we measured  HIF3A  mRNA expression and analyzed its correlation with obesity and related traits. In subgroups of individuals, we investigated the effects on  HIF3A  genetic variants on its AT expression (N = 603) and methylation of CpG-sites (N = 87).  HIF3A  expression was significantly higher in SAT compared to VAT and correlated with obesity and parameters of AT dysfunction (including CRP and leucocytes count).  HIF3A  methylation at cg22891070 was significantly higher in VAT compared to SAT and correlated with BMI, abdominal SAT and VAT area. Rs8102595 showed a nominal significant association with AT  HIF3A  methylation levels as well as with obesity and fat distribution.  HIF3A  expression and methylation in AT are fat depot specific, related to obesity and AT dysfunction. Our data support the hypothesis that HIF pathways may play an important role in the development of AT dysfunction in obesity.

Hypoxia-inducible factor 3A gene expression and methylation in adipose tissue is related to adipose tissue dysfunction