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Fusarium graminearum  is an important pathogen of wheat and barley. In addition to severe yield losses, infested grains are often contaminated with harmful mycotoxins. In this study, we characterized the functions of  FgSSN3  kinase gene in different developmental and infection processes and gene regulation in  F. graminearum . The  FgSSN3  deletion mutant had a nutrient-dependent growth defects and abnormal conidium morphology. It was significantly reduced in DON production,  TRI  gene expression, and virulence. Deletion of  FgSSN3  also resulted in up-regulation of  HTF1  and  PCS1  expression in juvenile cultures, and repression of  TRI  genes in DON-producing cultures. In addition,  Fgssn3  was female sterile and defective in hypopodium formation and infectious growth. RNA-seq analysis showed that FgSsn3 is involved in the transcriptional regulation of a wide variety genes acting as either a repressor or activator. FgSsn3 physically interacted with C-type cyclin Cid1 and the  cid1  mutant had similar phenotypes with  Fgssn3 , indicating that FgSsn3 and Cid1 form the CDK-cyclin pair as a component of the mediator complex in  F. graminearum . Taken together, our results indicate that  FgSSN3  is important for secondary metabolism, sexual reproduction, and plant infection, as a subunit of mediator complex contributing to transcriptional regulation of diverse genes.

FgSsn3 kinase, a component of the mediator complex, is important for sexual reproduction and pathogenesis in Fusarium graminearum