English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Poly(ethylenimine) (PEI) and Ru(bpy) 3  2+ -doped silica (Ru-SiO 2 ) nanoparticles were simply mixed together to prepare a novel self-enhanced electrochemiluminescence (ECL) composite of Ru-SiO 2 @PEI. The hollow Ru-SiO 2 @PEI nanoparticles were used to build an ECL immunosensor for the analysis of neuron specific enolase (NSE). PEI not only assembled on the surface of Ru-SiO 2  nanoparticles through the electrostatic interaction to act as co-reactant for Ru(bpy) 3  2+  ECL, but also provided alkaline condition to etch the Ru-SiO 2  nanoparticles to form the hollow Ru-SiO 2 @PEI nanoparticles with porous shell. The unique structure of the Ru-SiO 2 @PEI nanoparticles loaded both a large amount of Ru(bpy) 3  2+  and its co-reactant PEI at the same time, which shortened the electron-transfer distance, thereby greatly enhanced the luminous efficiency and amplified the ECL signal. The developed immunosensor showed a wide linear range from 1.0 × 10 −11  to 1.0 × 10 −5  mg mL −1  with a low detection limit of 1.0 × 10 −11  mg mL −1  for NSE. When the immunosensor was used for the determination of NSE in clinical human serum, the results were comparable with those obtained by using enzyme-linked immunosorbent assay (ELISA) method. The proposed method provides a promising alternative for NSE analysis in clinical samples.

A novel self-enhanced electrochemiluminescence immunosensor based on hollow Ru-SiO2@PEI nanoparticles for NSE analysis