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The aim of this study was to discover small-molecule anticoagulants from  Scolopendra subspinipes mutilans  (SSM). A new acylated polyamine ( 1 ) and a new sulfated quinoline alkaloid ( 2 ) were isolated from SSM. Treatment with the new alkaloids  1 ,  2 , and indole acetic acid  4  prolonged the activated partial thromboplastin time and prothrombin time and inhibited the activity and production of thrombin and activated factor X. Furthermore, compounds  1 ,  2 , and  4  inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation. In accordance with these potential  in vitro  antiplatelet activities, compounds  1 ,  2 , and  4  showed enhanced antithrombotic effects in an  in vivo  pulmonary embolism and arterial thrombosis model. Compounds  1 ,  2 , and  4  also elicited anticoagulant effects in mice. Collectively, this study may serve as the groundwork for commercializing SSM or compounds  1 ,  2 , and  4  as functional food components for the prevention and treatment of pathogenic conditions and serve as new scaffolds for the development of anticoagulants.

Antithrombotic and antiplatelet activities of small-molecule alkaloids from Scolopendra subspinipes mutilans