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Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) are key regulators of multiple biological processes by altering gene expression at various levels. Apoptosis in vascular endothelial cells (VECs) is closely linked to numerous cardiovascular diseases, such as arteriosclerosis, thrombus formation and plaque erosion. However, studies on lncRNAs in the cardiovascular system are just beginning. And thus far, no anti-apoptosis lncRNAs have been identified in VECs. Here, we focused on the anti-apoptosis roles of lncRNAs in the serum and FGF-2 starvation-induced apoptosis of VECs. Using microarray analysis, we found a novel lncRNA  LOC100129973  which acted as an apoptosis inhibitor in VECs. Through sponging  miR-4707-5p  and  miR-4767 , lncRNA  LOC100129973  upregulated the expression of two apoptosis repressors gene, Apoptosis  Inhibitor 5  ( API5 ) and  BCL2 like 12  ( BCL2L12 ), and thus alleviated the serum and FGF-2 starvation-induced apoptosis in VECs. This evidence suggests that lncRNA  LOC100129973  is an attractive target to improve endothelial function and for therapy of apoptosis related cardiovascular diseases.

Long Noncoding RNA LOC100129973 Suppresses Apoptosis by Targeting miR-4707-5p and miR-4767 in Vascular Endothelial Cells