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The ATP-dependent chromatin remodeling factors regulate gene expression. However, it is not known whether these factors regulate each other. Given the ability of these factors to regulate the accessibility of DNA to transcription factors, we postulate that one ATP-dependent chromatin remodeling factor should be able to regulate the transcription of another ATP-dependent chromatin remodeling factor. In this paper, we show that BRG1 and SMARCAL1, both members of the ATP-dependent chromatin remodeling protein family, regulate each other. BRG1 binds to the  SMARCAL1  promoter, while SMARCAL1 binds to the  brg1  promoter. During DNA damage, the occupancy of SMARCAL1 on the  brg1  promoter increases coinciding with an increase in BRG1 occupancy on the  SMARCAL1  promoter, leading to increased  brg1  and  SMARCAL1  transcripts respectively. This is the first report of two ATP-dependent chromatin remodeling factors regulating each other.

Transcriptional Regulation of Atp-Dependent Chromatin Remodeling Factors: Smarcal1 and Brg1 Mutually Co-Regulate Each Other