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The present study was conducted to investigate the effects of a high-lipid diet (HLD) on cyclooxygenase (Cox)-2 expression and the signalling pathways related to low-grade inflammation in the large yellow croaker ( Larmichthys crocea ). An isolated 2508 bp cDNA clone of  cox- 2 contained an open reading frame spanning 1827 bp encoding a protein with 608 amino acid residues. The over-expression of  cox-2  was consistent with the activation of c-Jun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinase (MAPK) in HLD-fed fish. The activation of the activator protein-1 (AP-1) and the nuclear transcription factor kappa-B (NF-κB) signalling pathways in HLD-fed fish and the significant increase of  cox-2  promoter-luciferase activity  in vitro  indicated that AP-1 and NF-κB could combine  cox-2  promoter to promote its transcription, respectively. Together, HLD-induced inflammation up-regulates  cox-2  expression via JNKs and p38 MAPK-dependent NF-κB and AP-1 pathways. The present study provides important insight into the signal transduction pathways involved in HLD-induced inflammation, which is detrimental to the health and production of fish as well as to the health of fish consumers.

Characterization of Cyclooxygenase-2 and its induction pathways in response to high lipid diet-induced inflammation in Larmichthys crocea