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Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of  Faecalibacterium prausnitzii  presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether  F. prausnitzii  may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus,  F. prausnitzii  exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.

Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models