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Chemical investigation on the methanol extract of  Chaetomium globosum  TW1-1, a fungus isolated from the common pillbug ( Armadillidium vulgare ), has resulted in the isolation of nine new highly oxygenated cytochalasan alkaloids, armochaetoglobins S–Z ( 1  and  3 – 9 ) and 7- O -acetylarmochaetoglobin S ( 2 ), together with eight structurally related known analogues ( 10 – 17 ). Their structures and absolute configurations were elucidated by spectroscopic analyses. Among them, compound  2  presents to be the first member of chaetoglobosin family with an acetyl group, and compounds  3  represents the first chaetoglobosin characterized by an 2′,3′-epoxy-indole moiety. The discovery of these new compounds revealed the largely untapped chemical diversity of cytochalasans and enriched their chemical research. Compounds  1 – 9  were evaluated for their cytotoxic activities against five human cancer cell lines, and compounds  8  and  9  exhibited significant cytotoxic activities with IC 50  values ranging from 10.45 to 30.42  μ M.

Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales)