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A total of 79 capsular types have been reported in  Klebsiella  spp., whereas capsular polysaccharide synthesis ( cps ) regions were available in only 22 types. Due to the limitations of serotyping, complete repertoire of  cps  will be helpful for capsular genotyping. We therefore resolved the rest 57  cps  and conducted comparative analysis. Clustering results of 1,515 predicted proteins from  cps  loci categorized proteins which share similarity into homology groups (HGs) revealing that 77 Wzy polymerases were classified into 56 HGs, which indicate the high specificity of  wzy  between different types. Accordingly,  wzy -based capsular genotyping could differentiate capsule types except for those lacking  wzy  (K29 and K50), those sharing identical  wzy  (K22 vs. K37); and should be carefully applied in those exhibited high similarity (K12 vs. K41, K2 vs. K13, K74 vs. K80, K79 vs. KN1 and K30 vs. K69). Comparison of CPS structures in several capsular types that shared similarity in their gene contents implies possible functions of glycosyltransferases. Therefore, our results provide complete set of  cps  in various types of  Klebsiella  spp., which enable the understandings of relationship between genes and CPS structures and are useful for identification of documented or new capsular types.

Genetic analysis of capsular polysaccharide synthesis gene clusters in 79 capsular types of Klebsiella spp