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To understand the cellular mechanism underlying the therapeutic effects exerted by hematopoietic stem cell transplantation in the repair of tissue damage, we investigated the  in vivo  dynamics of bone marrow (BM) lineage-negative (Lin − ) cells transplanted into mice with hyper sensitivity dermatitis. Longitudinal  in vivo  imaging and flow cytometry analyses revealed that Lin −  cells home directly to inflamed skin within 6 h, where they undergo extensive expansion with the peak on day 14 post-transplantation, and preferential differentiation into CD11b + Ly6G int Ly6C +  cells by day 7. Cells with phenotypic profiles of neutrophils, macrophages, and DCs appeared in inflamed skin on day 14. Progenies of transplanted Lin −  cells showed similar kinetics of expansion and myeloid differentiation in BM. However, differentiation into CD11b + Ly6G int Ly6C +  cells in the inflamed skin on day 7 was more skewed toward CD115 +  cells (≥60%) with immune suppressive function and higher expression levels of iNOS, arginase, and IL-10, compared with those in the BM. Transplantation of Lin −  cells reduced the levels of  Cd3  transcript and CD4 + /CD8 +  cells in inflamed skin. These results demonstrate differentiation of transplanted Lin −  cells into myeloid-derived suppressor cells in inflamed skin to be the basis of the alleviation of skin inflammation after Lin −  cell transplantation.

Alleviation of skin inflammation after Lin− cell transplantation correlates with their differentiation into myeloid-derived suppressor cells