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Recently, induced pluripotent stem cells (iPSCs) have been generated  in vivo  from reprogrammable mice. These  in vivo  iPSCs display features of totipotency, i.e., they differentiate into the trophoblast lineage, as well as all 3 germ layers. Here, we developed a new reprogrammable mouse model carrying an  Oct4 -GFP reporter gene to facilitate the detection of reprogrammed pluripotent stem cells. Without doxycycline administration, some of the reprogrammable mice developed aggressively growing teratomas that contained  Oct4 -GFP +  cells. These teratoma-derived  in vivo  PSCs were morphologically indistinguishable from ESCs, expressed pluripotency markers, and could differentiate into tissues of all 3 germ layers. However, these  in vivo  reprogrammed PSCs were more similar to  in vitro  iPSCs than ESCs and did not contribute to the trophectoderm of the blastocysts after aggregation with 8-cell embryos. Therefore, the ability to differentiate into the trophoblast lineage might not be a unique characteristic of  in vivo  iPSCs.

In vivo reprogrammed pluripotent stem cells from teratomas share analogous properties with their in vitro counterparts