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Aberrantly expressed long noncoding RNAs (lncRNAs) are associated with various cancers. However, the roles of lncRNAs in the pathogenesis of most cancers are unclear. Here, we report that the lncRNA  FER1L4  (fer-1-like family member 4, pseudogene) acts as a competing endogenous RNA (ceRNA) to regulate the expression of  PTEN  (a well-known tumor suppressor gene) by taking up miR-106a-5p in gastric cancer. We observed that  FER1L4  was downregulated in gastric cancer and that its level corresponded with that of  PTEN  mRNA. Both  FER1L4  and  PTEN  mRNA were targets of miR-106a-5p. Further experiments demonstrated that  FER1L4  downregulation liberates miR-106a-5p and decreases the abundances of  PTEN  mRNA and protein. More importantly,  FER1L4  downregulation accelerated cell proliferation by promoting the G 0 /G 1  to S phase transition. We conclude that one mechanism by which lncRNAs function in in tumorigenesis is as ceRNAs for tumor suppressor mRNAs.

Long noncoding RNA FER1L4 suppresses cancer cell growth by acting as a competing endogenous RNA and regulating PTEN expression