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Fungal pathogens have evolved antioxidant defense against reactive oxygen species produced as a part of host innate immunity. Recent studies proposed peroxidases as components of antioxidant defense system. However, the role of fungal peroxidases during interaction with host plants has not been explored at the genomic level. Here, we systematically identified peroxidase genes and analyzed their impact on fungal pathogenesis in a model plant pathogenic fungus,  Magnaporthe oryzae . Phylogeny reconstruction placed 27 putative peroxidase genes into 15 clades. Expression profiles showed that majority of them are responsive to  in planta  condition and  in vitro  H 2 O 2 . Our analysis of individual deletion mutants for seven selected genes including  MoPRX1  revealed that these genes contribute to fungal development and/or pathogenesis. We identified significant and positive correlations among sensitivity to H 2 O 2 , peroxidase activity and fungal pathogenicity. In-depth analysis of  MoPRX1  demonstrated that it is a functional ortholog of thioredoxin peroxidase in  Saccharomyces cerevisiae  and is required for detoxification of the oxidative burst within host cells. Transcriptional profiling of other peroxidases in Δ Moprx1  suggested interwoven nature of the peroxidase-mediated antioxidant defense system. The results from this study provide insight into the infection strategy built on evolutionarily conserved peroxidases in the rice blast fungus.

Systematic characterization of the peroxidase gene family provides new insights into fungal pathogenicity in Magnaporthe oryzae