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Acinetobacter pittii  44551 was recovered from a patient with gout combined with tuberculosis and was found to harbor the carbapenemase genes  bla  NDM-1  and  bla  OXA-58  on two different plasmids pNDM-44551 and pOXA58-44551, respectively. pNDM-44551 displayed high self-transferability across multiple bacterial species, while pOXA58-44551 was likely co-transferable with pNDM-44551 into  A. baumannii  receipts. pNDM-44551 was a close variant of the previously characterized pNDM-BJ01, and the  bla  NDM-1  gene cluster was arranged sequentially as  orfA , IS Aba14 ,  aphA6 , IS Aba125 ,  bla  NDM-1 ,  ble  MBL ,  ΔtrpF ,  dsbC ,  tnpR , and  zeta . pOXA58-44551 was a repAci9-containing plasmid, and  bla  OXA-58  was embedded in a  372F -IS Aba3 -like- bla  OXA-58 -IS Aba3  structure. The mobile genetic platforms of  bla  NDM-1  and  bla  OXA-58  herein showed some differences from their previously characterized variants. The production of NDM-1 in strain 44551 contributed the majority to its high resistance to carbapenems, while the  bla  OXA-58  stayed silent most likely due to the lack of an upstream promoter to drive its transcription. Increased surveillance of  Acinetobacter  co-harboring  bla  NDM-1  (active) and  bla  OXA-58  (either active or silent) is urgently needed.

“Roar” of blaNDM-1 and “silence” of blaOXA-58 co-exist in Acinetobacter pittii