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H 2 S is the third endogenously generated gaseous signaling compound and has also been known to involve a variety of physiological processes. To better understand its physiological and pathological functions, efficient methods for monitoring of H 2 S are desired. Azide fluorogenic probes are popular because they can take place bioorthogonal reactions. In this work, by employing a fluorescein derivative as the fluorophore and an azide group as the recognition unit, we reported a new probe 5-azidofluorescein for H 2 S with improved sensitivity and selectivety. The probe shows very low background fluorescence in the absence of H 2 S. In the presence of H 2 S, however, a significant enhancement for excited fluorescence were observed, resulting in a high sensitivity to H 2 S in buffered (10 mmol/L HEPES, pH 7.0) aqueous acetonitrile solution (H 2 O/CH 3 CN = 1:3, v/v) with a detection limit of 0.035  μ mol/L observed, much lower than the previously reported probes. All these features are favorable for direct monitoring of H 2 S with satisfactory sensitivity, demonstrating its value of practical application.

Highly selective fluorescent and colorimetric probe for live-cell monitoring of sulphide based on bioorthogonal reaction