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Arthrobacter  is one of the most prevalent genera of nicotine-degrading bacteria; however, studies of nicotine degradation in  Arthrobacter  species remain at the plasmid level (plasmid pAO1). Here, we report the bioinformatic analysis of a nicotine-degrading  Arthrobacter aurescens  M2012083, and show that the  moeB  and  mogA  genes that are essential for nicotine degradation in  Arthrobacter  are absent from plasmid pAO1. Homologues of all the nicotine degradation-related genes of plasmid pAO1 were found to be located on a 68,622-bp DNA segment ( nic  segment-1) in the M2012083 genome, showing 98.1% nucleotide acid sequence identity to the 69,252-bp  nic  segment of plasmid pAO1. However, the rest sequence of plasmid pAO1 other than the  nic  segment shows no significant similarity to the genome sequence of strain M2012083. Taken together, our data suggest that the nicotine degradation-related genes of strain M2012083 are located on the chromosome or a plasmid other than pAO1. Based on the genomic sequence comparison of strain M2012083 and six other  Arthrobacter  strains, we have identified 17 σ 70  transcription factors reported to be involved in stress responses and 109 genes involved in environmental adaptability of strain M2012083. These results reveal the molecular basis of nicotine degradation and survival capacities of  Arthrobacter  species.

Comparative genome analysis reveals the molecular basis of nicotine degradation and survival capacities of Arthrobacter