English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Tumor suppressor Trp53 works as a guardian of the genome in somatic cells. In mouse embryonic stem (ES) cells, it was reported that Trp53 represses pluripotency-associated transcription factor  Nanog  to induce differentiation. However, since  Trp53 -null mice develop to term,  Trp53  is dispensable for both the maintenance and differentiation of the pluripotent stem cell population  in vivo , suggesting the differential functions of Trp53 in ES cells and embryos. To reveal the basis of this discrepancy, here we established a new line of  Trp53 -null ES cells by sequential gene targeting and evaluated their ability to differentiate  in vitro  and  in vivo . We found that  Trp53 -null ES cells had defects in differentiation  in vitro  as reported previously, whereas they were able to contribute to normal development in chimeric embryos. These data indicated that the requirement of  Trp53  for maintaining and executing the ES pluripotency is not absolute.

Maintenance of pluripotency in mouse ES cells without Trp53