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Although autoantibody detection has been proposed for diagnosis of colorectal cancer, little is known abouttheir initial production and development correlation with cancer progression. Azoxymethane/dextransodium sulfate (AOM/DSS)-treated mice developed colon adenocarcinoma in the distal colon similar tohuman sporadic colon cancer. We assessed this model together with AOM and DSS-only models for theirapplicability to early detection of cancer. All AOM/DSS-treated mice produced autoantibodies totumor-associated antigens analogous to those observed in human colon cancer patients. Autoantibodyresponse was related to tumor antigen overexpression. Cancer autoantibodies were detected 21 days afterstarting treatment, when no malignant histopathological features were detectable, and they increasedaccording to tumor progression. When carcinogenesis was induced separately by AOM or DSS, only thosemice that developed malignant lesions produced significant levels of autoantibodies. These findingsdemonstrate that autoantibody development is an early event in tumorigenesis and validates its use forpreclinical colon cancer diagnosisR. Barderas was a JAE-DOC fellow of the CSIC and is currently a recipient of the Ramón yCajal programme of theMINECO. R. Villar-Vázquez was a recipient of a FPU fellowship ofthe Ministry of Education of Spain. Alberto Peláez was a recipient of a FPI fellowship fromtheMINECO. Sofia Torres was a fellow from the Juan de la Cierva programme (MINECO).This study was supported by grant BIO2012-31023 from the MINECO, a grant toestablished research groups of the Asociaciópn Española Contra el Cáncer and the grantS2010/BMD-2344/Colomics2 from Comunidad de Madri

Sporadic colon cancer murine models demonstrate the value of autoantibody detection for preclinical cancer diagnosis