Open AccessDynamics and stability analysis of the growth and astaxanthin production system of Haematococcus pluvialis
Author(s) -
X-W Zhang,
Xiaowen Gong,
Feng Chen
Publication year - 1999
Publication title -
journal of industrial microbiology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 112
eISSN - 1476-5535
pISSN - 1367-5435
DOI - 10.1038/sj.jim.2900704
Subject(s) - haematococcus pluvialis , astaxanthin , bioreactor , substrate (aquarium) , steady state (chemistry) , product inhibition , yield (engineering) , kinetics , dilution , chemistry , growth rate , chromatography , biophysics , biochemistry , biology , thermodynamics , enzyme , mathematics , non competitive inhibition , ecology , physics , organic chemistry , quantum mechanics , carotenoid , geometry
This paper investigated high cell density cultivation of Haematococcus pluvialis for astaxanthin production in 3.7-L bioreactors. A biomass concentration of 2.74 g L-1and an astaxanthin yield of 64.4 mg L-1 were obtained. Based on the experimental results, a new and simple dynamic model is proposed, differing from Monod kinetics, to describe cell growth, product formation and substrate consumption. Good agreement was found between the model predictions and experimental data. The model revealed that there was cell growth inhibition on product formation and product feedback compensation for substrate consumption, but no substrate inhibition or product inhibition of cell growth. Stability analysis demonstrated that no multiplicity of steady states was observed; the unique positive steady state was locally asymptotically stable; and the effect of dilution rate on steady states was greater than that of the initial substrate concentration.
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