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[ 11 C]PE2I is a novel positron emission tomography (PET) radiotracer for the dopamine transporter (DAT). The reproducibility and reliability of [ 11 C]PE2I measurements, especially in the small DAT-rich brain regions, is unknown and of critical importance to the interpretation of the data. Five healthy volunteers were scanned twice during the same day using [ 11 C]PE2I and the HRRT PET scanner. Methods based on metabolite-corrected arterial plasma curve and reference region were used to estimate distribution volumes ( V T ) and binding potential ( BP). Within-subject and between-subject variabilities were compared. [ 11 C]PE2I accumulated in the DAT-rich striatum and the midbrain. Equilibrium of specific binding appeared late in the striatum, whereas it was reached earlier in the midbrain. Plasma metabolite analysis showed that the potentially brain-penetrant 4-hydroxymethyl metabolite represented 15% to 20% of total plasma radioactivity. V T  and BP measurements were associated with low within-subject variability. Measurement of DAT binding in small brain regions, including the substantia nigra, is reproducible and reliable using [ 11 C]PE2I and high-resolution research tomograph. A scanning time of more than 70 mins is required for the striatum, while less is sufficient for DAT quantification in the midbrain. The previously suggested involvement of the potentially brain-penetrant radioactive metabolite in the quantification should be further studied.

journal of cerebral blood flow and metabolism

Measurement of Striatal and Extrastriatal Dopamine Transporter Binding with High-Resolution PET and [<sup>11</sup>C]PE2I: Quantitative Modeling and Test—Retest Reproducibility

Measurement of Striatal and Extrastriatal Dopamine Transporter Binding with High-Resolution PET and [11C]PE2I: Quantitative Modeling and Test—Retest Reproducibility

Measurement of Striatal and Extrastriatal Dopamine Transporter Binding with High-Resolution PET and [¹¹C]PE2I: Quantitative Modeling and Test—Retest Reproducibility