English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The dopamine D 1  receptor antagonist radioligand [ 11 C]NNC 112 has previously been reported to have 100-fold selectivity for the D 1  receptor compared with the serotonin 5-HT 2A  receptor. In this study, we tested the selectivity by scanning seven healthy human research volunteers with [ 11 C]NNC 112 before and after 2mg of the antipsychotic drug risperidone, a dose that putatively blocks all 5-HT 2A  receptors with negligible effect on D 1  receptors. We found that specific binding in cortical regions was reduced by 20% to 30%, whereas the striatum showed no change. Based on the known relative densities of these receptors in humans, our results suggest 5- to 10-fold selectivity of [ 11 C]NNC 112 for D 1  versus 5-HT 2A  as opposed to 100-fold selectivity. These results suggest caution in interpreting data from studies using this tracer to measure cortical D 1  receptors as well as the need for more selective radioligands to assess cortical D 1  receptors.

[11C]NNC 112 Selectivity for Dopamine D1and Serotonin 5-HT2AReceptors: A PET Study in Healthy Human Subjects

[¹¹C]NNC 112 Selectivity for Dopamine D₁and Serotonin 5-HT_2AReceptors: A PET Study in Healthy Human Subjects