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Ability to image cerebral metabolic rate of oxygen (CMRO 2 ) is essential for studying the fundamental role of oxidative metabolism in brain function and disease. We have demonstrated recently that three-dimensional (3D) CMRO 2  images can be obtained in the rat brain during a 2-min  17 O 2  inhalation using the  17 O MR spectroscopic imaging (MRSI) approach at high field. The feasibility for establishing a completely noninvasive approach for imaging CMRO 2  has also been demonstrated. In this study, we further explored the feasibility of  17 O MRSI approach for performing repeated CMRO 2  measurements within a short period of time and evaluated the reproducibility of the repeated measurements. Subsequently, we applied the  17 O MRSI approach to measure CMRO 2  and cerebral blood flow (CBF) values at two brain temperatures in the α-chloralose anesthetized rat brain at 9.4 T. Finally, we tested the validity of simplified model for noninvasively determining CMRO 2  in normothermic and hypothermic rat brain. The results show (i) an excellent reproducibility among repeated measurements of 3D CMRO 2  images under the same physiologic condition; (ii) a 44% decrease of CMRO 2  across the rat brain at mild hypothermic (32°C) condition as compared with normothermic (37°C) condition; and (iii) a close correlation between CMRO 2  and CBF within a relatively wide physiologic range. This study demonstrates the capability of  17 O MRSI approach for noninvasively imaging CMRO 2  and its changes caused by physiologic perturbation. This approach, thus, should provide a promising neuroimaging modality for studying oxidative metabolism and bioenergetics associated with brain functions and diseases.

Noninvasive and Three-Dimensional Imaging of CMRO2 in Rats at 9.4 T: Reproducibility Test and Normothermia/Hypothermia Comparison Study

Noninvasive and Three-Dimensional Imaging of CMRO₂ in Rats at 9.4 T: Reproducibility Test and Normothermia/Hypothermia Comparison Study