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In an in vitro study, fixed-combination fortified vancomycin and amikacin ophthalmic solutions (VA solution) had the same potency and stable physical properties as the separate components. In this retrospective clinical study, we evaluated the efficacy of the topical VA solution in the treatment of bacterial corneal ulcer and comparison with separate topical fortified vancomycin and amikacin.

Comparison of topical fixed-combination fortified vancomycin–amikacin (VA solution) to conventional separate therapy in the treatment of bacterial corneal ulcer