Open AccessEpigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy
Author(s) -
Samson T. Jacob,
Tasneem Motiwala
Publication year - 2005
Publication title -
cancer gene therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.535
H-Index - 86
eISSN - 1476-5500
pISSN - 0929-1903
DOI - 10.1038/sj.cgt.7700828
Subject(s) - epigenetics , methyltransferase , dna methylation , methylation , protein tyrosine phosphatase , biology , gene silencing , gene , suppressor , cancer epigenetics , histone , histone methyltransferase , tumor suppressor gene , cancer research , tyrosine , genetics , carcinogenesis , biochemistry , gene expression
Promoter methylation-mediated silencing is a hallmark of many established tumor suppressor genes. This review focuses on the methylation and suppression of a receptor-type tyrosine phosphatase gene, PTPRO, in a variety of solid and liquid tumors. In addition, PTPRO exhibits many other characteristics of a bona fide tumor suppressor. Reactivation of genes silenced by methylation using inhibitors of DNA methyltransferases and histone deacetylases, and the potential application of PTPRO as a molecular target for cancer therapy have been discussed.