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The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(-1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9(-1562C&gt;T) was not. Tumour MMP levels were not determined by their SNP genotypes.

MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not