English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Sir, We read with interest the comments regarding a possible relationship between female carriers of ataxia telangiectasia (AT) with susceptibility to low-dose ionising radiation and the induction of breast cancers in women of screening age. Although MR mammography does not use ionising radiation, its use in screening of women at a high risk of breast cancer is currently being evaluated, both because of the inherent high sensitivity of the technique, especially in dense pre-menopausal breast tissue and the safety issues particularly in Li-Fraumeni syndrome. The UK Magnetic Resonance Imaging for Breast Screening study (MARIBS) is a multicentre ongoing trial comparing the efficacy of X-ray mammography and MRI as a method for screening genetically high-risk women aged 35–50 years. This trial will close in 2005. Results from Kuhl et al (2003) and Kriege et al (2003) presented recently at the American Society of Clinical Oncology, relating to similar trials again of genetically high-risk subjects have indicated promising results. The authors are unaware of any current trials comparing imaging modalities for screening the 50–64-year age group, or indeed if such a trial is contemplated. The results of such a comparison including health economic issues would need to be very carefully evaluated before embarking on a long-term follow-up trial to elucidate the risks of screening using techniques dependent on ionising radiation.

Reply: Improved safety and effectiveness of imaging predicted for MR mammography