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A method of studying the effect of drugs on the lower urinary tract is described, using cord-injured patients with detrusor hyperreflexia. In this study 19 patients received intravenous phentolamine. This alpha-adrenergic blockade produced a significant reduction in the maximum voiding detrusor pressure, voided volumes and peak flow rates with no reduction of outflow tract obstruction.

The use of urodynamic studies to assess the effect of pharmacological agents with particular references to alpha-adrenergic blockade